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Pharmacokinetics of liposome-entrappedcis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II) and cisplatin given i.v. and i.p. in the rat

✍ Scribed by Kiumars Vadiei; Zahid H. Siddik; Abdul R. Khokhar; Salam Al-Baker; Federico Sampedro; Roman Perez-Soler

Publisher: Springer
Year: 1992
Tongue: English
Weight: 603 KB
Volume: 30
Category: Article
ISSN: 0344-5704
DOI: 10.1007/bf00689964

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Blood and tissue levels of elemental platinum (Pt) were measured after the administration of a liposomally entrapped cisplatin analogue, cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) (L-NDDP). In mice bearing subcutaneous B16 melanoma tumors, Pt tumor levels were not significan