Intraliposomal conversion of lipophilic cis-bis-carboxylato-trans-R, R-1, 2-diaminocyclohexane-platinum (II) complexes into cis-bis-dichloro-trans-R, R-1,2-diaminocyclohexane-platinum (II)
β Scribed by Han. Insook; Abdul R. Khokhar; R. Perez-Soler
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 236 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0344-5704
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## Abstract Several palladium(II) and platinum(II) complexes analogous to oxaliplatin, bearing the enantiomerically pure (1__R__,2__R__)β(β)β1,2βdiaminocyclohexane (DACH) ligand, of the general formula {MX~2~[(1__R__,2__R__)βDACH]}, where M = Pd or Pt, X $= {1 \over 2}$ (COO)~2~, ${1 \over 2}$ CH~2
Blood and tissue levels of elemental platinum (Pt) were measured after the administration of a liposomally entrapped cisplatin analogue, cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) (L-NDDP). In mice bearing subcutaneous B16 melanoma tumors, Pt tumor levels were not significan