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Palladium(II) and platinum(II) complexes of (1R,2R)-(−)-1,2-diaminocyclohexane (DACH) with various carboxylato ligands and their cytotoxicity evaluation

✍ Scribed by Talal A.K. Al-Allaf; Luay J. Rashan; Gerhard Ketler; Heinz-Herbert Fiebig; Amar H. Al-Dujaili

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
144 KB
Volume
23
Category
Article
ISSN
0268-2605

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✦ Synopsis

Abstract

Several palladium(II) and platinum(II) complexes analogous to oxaliplatin, bearing the enantiomerically pure (1__R__,2__R__)‐(−)‐1,2‐diaminocyclohexane (DACH) ligand, of the general formula {MX~2~[(1__R__,2__R__)‐DACH]}, where M = Pd or Pt, X $= {1 \over 2}$ (COO)~2~, ${1 \over 2}$ CH~2~(COO)~2~, , , ${1 \over 2}${1,1′‐C~5~H~8~(CH~2~COO)~2~}, ${1 \over 2}$[1,1′‐C~6~H~10~(CH~2~COO)~2~], ${1 \over 2}$[1,1′‐(COO)~2~ferrocene], , , , MeCOO and Me~3~CCOO, were synthesized. All the complexes prepared were characterized physicochemically and spectroscopically. Some selected complexes were screened in vitro against several tumor cell lines and the results were compared with reference standard drug, oxaliplatin. Copyright © 2009 John Wiley & Sons, Ltd.

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