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PRECLINICAL STUDY: Disposition of Δ9 tetrahydrocannabinol in CF1 mice deficient in mdr1a P-glycoprotein

✍ Scribed by Laurence Bonhomme-Faivre; Amine Benyamina; Michel Reynaud; Robert Farinotti; Chadi Abbara


Book ID
110881238
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
146 KB
Volume
13
Category
Article
ISSN
1355-6215

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The subpopulation of CF-1 mice deficient
✍ Todd R. Pippert; Diane R. Umbenhauer 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 201 KB

## Abstract A subpopulation of the CF‐1 mouse strain is sensitive to neurotoxicity following exposure to avermectins, a family of structurally related antiparasitic agents. This unusual sensitivity is the result of a deficiency in the mdr1a P‐glycoprotein that normally contributes to a functional b