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Lack of difference in pulmonary absorption of digoxin, a P-glycoprotein substrate, in mdr1a-deficient and mdr1a-competent mice

✍ Scribed by Fergus Manford; Yanira Riffo-Vasquez; Domenico Spina; Clive P. Page; Andrew J. Hutt; Vanessa Moore; Fredrik Johansson; Ben Forbes

Book ID: 111770752
Publisher: Pharmaceutical Press
Year: 2008
Tongue: English
Weight: 118 KB
Volume: 60
Category: Article
ISSN: 2042-7158
DOI: 10.1211/jpp.60.10.0006

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## Abstract A subpopulation of the CF‐1 mouse strain is sensitive to neurotoxicity following exposure to avermectins, a family of structurally related antiparasitic agents. This unusual sensitivity is the result of a deficiency in the mdr1a P‐glycoprotein that normally contributes to a functional b