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A Structure-Function Approach to Study ABCB1 (mdr1/P-Glycoprotein) Pharmacogenomics in Drug Disposition

✍ Scribed by White, Alana A.; Ross, J.B. Alexander; Woodahl, Erica L.

Book ID
119208688
Publisher
Biophysical Society
Year
2011
Tongue
English
Weight
36 KB
Volume
100
Category
Article
ISSN
0006-3495

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In the mouse, both the mdr1a and the mdr1b gene encode drug-transporting P-glycoproteins. The mdr1a P-glycoprotein is expressed in epithelial cells of, among others, the liver and the intestine. Furthermore, the mdr1b gene product is found in the liver but is not detectable in the intestine. To esta