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Preclinical modeling of EGFR inhibitor resistance in head and neck cancer

✍ Scribed by Quesnelle, Kelly M.; Wheeler, Sarah E.; Ratay, Mary K.; Grandis, Jennifer R.

Book ID
115448925
Publisher
Landes Bioscience
Year
2012
Tongue
English
Weight
904 KB
Volume
13
Category
Article
ISSN
1538-4047

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## Abstract Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that activates multiple signaling pathways, including phosphatidylinositol‐3‐kinase/v‐AKT murine thymoma viral oncogene homolog protein (Akt), has long been a target of novel therapies. Despite universal EGFR expression