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Resistance to EGFR kinase inhibitor PD158780 in head and neck cancer cell lines

✍ Scribed by Mark James Jameson; Andrew D. Beckler; Christopher Y. Thomas; Michael J. Weber; Paul A. Levine


Book ID
116809597
Publisher
SAGE Publications
Year
2004
Tongue
English
Weight
35 KB
Volume
131
Category
Article
ISSN
0194-5998

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Mechanisms of resistance to EGFR inhibit
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## Abstract Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that activates multiple signaling pathways, including phosphatidylinositol‐3‐kinase/v‐AKT murine thymoma viral oncogene homolog protein (Akt), has long been a target of novel therapies. Despite universal EGFR expression