Alteration of pRb/p16/cdk4 regulation in
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M. Serena Benassi; Lara Molendini; Gabriella Gamberi; Paola Ragazzini; M. Rosa S
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Article
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1999
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John Wiley and Sons
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French
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Cell-cycle regulation depends on a fine balance between cyclin-cyclin-dependent kinase complexes and a family of kinase inhibitors that bind cyclin-cdk complexes and block their activity. To investigate the role of mechanisms regulating cell-cycle progression in human osteosarcomas (OS), pRb/p16/cdk