✦ LIBER ✦

Alterations of the p53 and pRB pathways in human astrocytoma

✍ Scribed by James T. Rutka; Yasuhiko Akiyama; Sang Pyung Lee; Stacey Ivanchuk; Atsushi Tsugu; Paul A. Hamel

Publisher: Springer Japan
Year: 2000
Tongue: English
Weight: 940 KB
Volume: 17
Category: Article
ISSN: 1433-7398
DOI: 10.1007/bf02482737

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Alterations of retinoblastoma, p53, p16(

Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas

✍ Toshihide Tsuzuki; Shigeru Tsunoda; Toshisuke Sakaki; Noboru Konishi; Yoshio Hia 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 637 KB

## BACKGROUND. Alterations of the suppressor genes, such as the retinoblastoma (RB), p53, pl6(CDKN2), and p15 genes, have been reported in human gliomas. These genes have been suggested as the cell cycle regulatory genes at the G,-S checkpoint.

Tumorigenesis in p27/p53- and p18/p53-do

Tumorigenesis in p27/p53- and p18/p53-double null mice: Functional collaboration between the pRb and p53 pathways

✍ Lorna A. Damo; Paul W. Snyder; David S. Franklin 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 604 KB

Mice lacking both p18 Ink4c and p27 Kip1 develop a tumor spectrum similar to pRb þ/À mice, and loss of p53 function accelerates tumorigenesis in pRb þ/À mice. We hypothesized that codeletion of either p18 or p27 in conjunction with p53 deletion will also accelerate tumorigenesis. Mice lacking both p

Immortalization of oral keratinocytes by

Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways

✍ Serge J. Smeets; Marlon van der Plas; Tieneke B.M. Schaaij-Visser; Eva A.M. van 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 638 KB

## Abstract A subgroup of head and neck squamous cell carcinomas (HNSCCs) contains high‐risk human papillomavirus‐type 16 (HPV16). The viral E6 and E7 oncoproteins inactivate the p53 and pRb proteins, respectively. We examined the causative effect of HPV16 E6 and E7 expression on the immortalizatio

The p53 pathway and human cancer

✍ T. Soussi 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 62 KB

Alterations in p53, p21, and MIB-1 Label

Alterations in p53, p21, and MIB-1 Labeling Index in Primary Human Astrocytomas Following Radiation Therapy

✍ John W. Henson; Wendy Hobbs; Arnab Chakravarti; David N. Louis 📂 Article 📅 2005 🏛 Springer US 🌐 English ⚖ 253 KB

Alteration of pRb/p16/cdk4 regulation in

Alteration of pRb/p16/cdk4 regulation in human osteosarcoma

✍ M. Serena Benassi; Lara Molendini; Gabriella Gamberi; Paola Ragazzini; M. Rosa S 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 280 KB 👁 1 views

Cell-cycle regulation depends on a fine balance between cyclin-cyclin-dependent kinase complexes and a family of kinase inhibitors that bind cyclin-cdk complexes and block their activity. To investigate the role of mechanisms regulating cell-cycle progression in human osteosarcomas (OS), pRb/p16/cdk