𝔖 Bobbio Scriptorium
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Loss of p16 and/or pRb protein expression in NSCLC

✍ Scribed by Chen, Jung-Ta; Chen, Yi-Chun; Chen, Chih-Yi; Wang, Yi-Ching

Book ID
118569484
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
514 KB
Volume
31
Category
Article
ISSN
0169-5002

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The retinoblastoma protein (pRB), p16, and cyclin D1 are major components of the RB pathway, which controls the G1 checkpoint of the cell cycle. Proper regulation of this pathway is crucial for normal cell proliferation. Abnormal forms of these proteins have been found in various types of malignant