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Alterations of p53, pRb, cyclin D1 and cdk4 in human oral and pharyngeal squamous cell carcinomas

✍ Scribed by S Koontongkaew; L Chareonkitkajorn; A Chanvitan; M Leelakriangsak; P Amornphimoltham

Book ID: 114394428
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 395 KB
Volume: 36
Category: Article
ISSN: 1368-8375
DOI: 10.1016/s1368-8375(99)00093-7

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## Abstract ## BACKGROUND Cyclin D1 (__CCND1__) and __p16__ alterations have been detected in oral squamous cell carcinomas (SCCs), suggesting that abnormalities of these genes may play an important role in the genesis or progression of oral SCCs and serve as independent prognostic indicators. The