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Alterations of Rb, p16INK4A and cyclin D1 in the tumorigenesis of oral squamous cell carcinomas

✍ Scribed by Yuuji Nakahara; Satoru Shintani; Mariko Mihara; Akihisa Kiyota; Yoshiya Ueyama; Tomohiro Matsumura

Book ID
117466644
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
319 KB
Volume
160
Category
Article
ISSN
0304-3835

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## Abstract ## BACKGROUND Cyclin D1 (__CCND1__) and __p16__ alterations have been detected in oral squamous cell carcinomas (SCCs), suggesting that abnormalities of these genes may play an important role in the genesis or progression of oral SCCs and serve as independent prognostic indicators. The