Alterations of the p16INK4a/Rb/cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosus
โ Scribed by Enrique Lerma; Manel Esteller; James G. Herman; Jaime Prat
- Book ID
- 117818662
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 202 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1532-8392
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Inactivation of the Rb pathway in non-small cell lung carcinoma (NSCLC) occurs mostly through inactivation of the cyclin-dependent kinase inhibitor p16 INK4A and/or up-regulation of cyclin D1. In order to assess the frequency and the prognostic value of these abnormalities in NSCLC, immunohisto
## Abstract Two pathways leading to vulvar squamous cell carcinoma (SCC) exist. The expression of proliferationโ and cellโcycleโrelated biomarkers and the presence of highโrisk (hr) HPV might be helpful to distinguish the premalignancies in both pathways. Seventyโfive differentiated vulvar intraโep