Practical synthetic approach to 4-acetoxy-2-azetidinone for the preparation of carbapenem and penem antibiotics
β Scribed by Guo-Bin Zhou; Yue-Qing Guan; He Tang; Yan-Bin Zhao; Li-Rong Yang
- Book ID
- 106518059
- Publisher
- Springer Netherlands
- Year
- 2011
- Tongue
- English
- Weight
- 359 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0922-6168
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π SIMILAR VOLUMES
A short stereoselective synthesis of the acetoxy azetidinone (1), an important precursor of several biologically active β€-lactam antibiotics, has been accomplished in seven steps and 32.8% overall yield from the easily available and inexpensive (R) ethyl 3-hydroxybutanoate.
A Practical Synthesis of 3-[(1R)-1-t-Butyldimethylsilyloxyethyl]-4-[(2R)-4-halo-3-oxo-2-butyl]azetidinone, a Versatile Intermediate for Carbapenem Antibiotics. -The readily available carboxylic acid (I) is converted efficiently by a three-step procedure into the title compounds such as (VI). Desily
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