Practical Synthesis of 2-Amino-5-fluorothiazole Hydrochloride
✍ Scribed by Briner, Paul H.; Fyfe, Matthew C. T.; Martin, Pierre; Murray, P. John; Naud, Frédéric; Procter, Martin J.
- Book ID
- 121497222
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 33 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1083-6160
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📜 SIMILAR VOLUMES
## Abstract A convenient synthesis of the ^14^C‐labelled chloromethyl ketone analog of leucine is reported. Modification of previously published conditions allowed for the facile synthesis of: 2–^14^C‐3‐amino‐1‐chloro‐5‐methylhexan‐2‐one hydrochloride in four steps from 1‐^14^C‐DL‐leucine in 85.7%
## Abstract 1‐[^15^N]Amino‐2‐propanol hydrochloride (**2**) was synthesized in three steps, i.e. Gabriel condensation of potassium [^15^N]phthalimide (**3**) with chloroacetone (**4**), reduction of the product ([^15^N]phthalimidoacetone (**5**)) with sodium borohydride, and hydrolysis in 33% total