Synthesis of D-1-hydroxy-2-amino-3-oxooctadecane-4,5-t2 hydrochloride
β Scribed by Weiss, Benjamin.; Stiller, Richard L.
- Book ID
- 126209966
- Publisher
- American Chemical Society
- Year
- 1970
- Tongue
- English
- Weight
- 593 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
## Synthesis of the title compound ( 5 ) . an histamine H2 -receptor antagonist, is described. Treatment of 3-(3-[2.6-C1-piperidinomethylphenoxv)propylamine(l)l with 3-amino-4-methoxy-l,2,5-thiadiazole-1-oxide2 produced 3-amino-4-13-0-[ 2,6-"C]piperidinomethylphenoxy)propylamino~-1,2,5-thiadiazole
## Abstract A convenient synthesis of the ^14^Cβlabelled chloromethyl ketone analog of leucine is reported. Modification of previously published conditions allowed for the facile synthesis of: 2β^14^Cβ3βaminoβ1βchloroβ5βmethylhexanβ2βone hydrochloride in four steps from 1β^14^CβDLβleucine in 85.7%