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Potentiation of cocaine hepatotoxicity in human hepatocytes by ethanol

✍ Scribed by Ponsoda, X.; Jover, R.; Castell, J.V.; Gómez-Lechón, M.J.

Book ID: 123326026
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 380 KB
Volume: 6
Category: Article
ISSN: 0887-2333
DOI: 10.1016/0887-2333(92)90009-G

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Cocaine remains a widely abused illicit substance in our society. Cocaine hepatotoxicity has been linked to cocaine metabolism. Cocaine can undergo hydrolytic inactivation via plasma and hepatic esterases or it can be N-oxidized by cytochrome P-450 and FAD-containing monooxygenases. Ethanol is frequ