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Potentiation of cocaine hepatotoxicity by ethanol in human hepatocytes

✍ Scribed by Ramiro Jover; Xavier Ponsoda; M.José Gómez-Lechón; Conrado Herrero; Javier Del Pino; JoséV. Castell

Book ID: 113207708
Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 756 KB
Volume: 107
Category: Article
ISSN: 0041-008X
DOI: 10.1016/0041-008x(91)90315-6

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Cocaine remains a widely abused illicit substance in our society. Cocaine hepatotoxicity has been linked to cocaine metabolism. Cocaine can undergo hydrolytic inactivation via plasma and hepatic esterases or it can be N-oxidized by cytochrome P-450 and FAD-containing monooxygenases. Ethanol is frequ