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Potentiation of carbon tetrachloride hepatotoxicity by ethanol and cold

✍ Scribed by E. Wei; L.C.K. Wong; C.H. Hine


Book ID
119001368
Publisher
Elsevier Science
Year
1971
Tongue
English
Weight
406 KB
Volume
18
Category
Article
ISSN
0041-008X

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Induction of P450IIE1 by pyridine was compared with that by ethanol, and the resulting potentiation of the pneumotoxicity and hepatotoxicity following carbon tetrachloride inhalation by pyridine was examined. Rats were treated with ethanol as either a 10% solution in the drinking water or as a daily

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To study the effect of an acute dose of ethanol on carbon tetrachloride (CC14) concentration and hepatotoxicity, female rats received ethanol (2.5 ml/kg body wt.) either intragastrically or intraperitoneally following intragastric administration of CC14 (1.5 ml/kg body wt.). Three hours after acute