Induction of P450IIE1 by pyridine was compared with that by ethanol, and the resulting potentiation of the pneumotoxicity and hepatotoxicity following carbon tetrachloride inhalation by pyridine was examined. Rats were treated with ethanol as either a 10% solution in the drinking water or as a daily
Mechanistic studies on the potentiation of carbon tetrachloride hepatotoxicity by methamphetamine
โ Scribed by Stephen M. Roberts; Raymond D. Harbison; Robert C. James
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 832 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0300-483X
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๐ SIMILAR VOLUMES
Chlordecone greatly potentiates carbon tetrachloride (CC14) hepatotoxicity. In order to quantitate the degree of this potentiation, the effects of a range of doses of C C 4 on two microsomal enzymatic functions and liver enzyme release were examined in chlordecone-treated and control rats. Male Spra
Carbon tetrachloride (CCl 4 ) is a model for studying free radical-induced liver injury and screening hepato-protective drugs. Numerous studies have reported the involvement of oxidative stress in CCl 4 -induced liver damage and the hepato-protective effects mediated by different antioxidants. The p
The mechanism by which taurine (2-aminoethanesulfonic acid) protects hepatocytes injury induced by carbon tetrachloride (CCl4) is not fully understood. In a previous study, we reported that cellular polyamines play an important role in this mechanism. The relationship between cellular glutathione (G