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Increased toxicity of cocaine on human hepatocytes induced by ethanol: role of GSH

✍ Scribed by Xavier Ponsoda; Roque Bort; Ramiro Jover; Marı́a José Gómez-Lechón; José V Castell

Book ID
113994581
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
364 KB
Volume
58
Category
Article
ISSN
0006-2952

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Cocaine remains a widely abused illicit substance in our society. Cocaine hepatotoxicity has been linked to cocaine metabolism. Cocaine can undergo hydrolytic inactivation via plasma and hepatic esterases or it can be N-oxidized by cytochrome P-450 and FAD-containing monooxygenases. Ethanol is frequ