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The effect of ethanol exposure on cocaine toxicity in rat hepatocytes

✍ Scribed by M.L. Figliomeni; M.S. Abdel-Rahman


Book ID
117587849
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
871 KB
Volume
11
Category
Article
ISSN
0887-2333

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Cocaine remains a widely abused illicit substance in our society. Cocaine hepatotoxicity has been linked to cocaine metabolism. Cocaine can undergo hydrolytic inactivation via plasma and hepatic esterases or it can be N-oxidized by cytochrome P-450 and FAD-containing monooxygenases. Ethanol is frequ