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Potentiation of Apomorphine Effect (Compulsive Gnawing Behaviour) in Mice

✍ Scribed by Pedersen, V.


Book ID
114798532
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
55 KB
Volume
25
Category
Article
ISSN
0001-6683

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In mice, apomorphine (10 mg/kg s.c.) does not induce a compulsion to gnaw, but pretreatment with antihistamines, viz. pheniramine, chlorpheniramine and mepyramine, in doses ranging from 30 to 60 mg/kg i.p. caused gnawing activity. Mepyramine showed significantly less effect when compared to the othe