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Pharmacological characterization of the enhancement of apomorphine-induced gnawing in mice by cocaine

✍ Scribed by Ezio Tirelli; Jeffrey M. Witkin

Book ID
113226895
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
839 KB
Volume
55
Category
Article
ISSN
0091-3057

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In mice, apomorphine (10 mg/kg s.c.) does not induce a compulsion to gnaw, but pretreatment with antihistamines, viz. pheniramine, chlorpheniramine and mepyramine, in doses ranging from 30 to 60 mg/kg i.p. caused gnawing activity. Mepyramine showed significantly less effect when compared to the othe