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Potentiation of apomorphine-induced gnawing in mice

โœ Scribed by Hedley, Linda R.; Wallach, Marshall B.


Book ID
122960306
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
548 KB
Volume
7
Category
Article
ISSN
0278-5846

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In mice, apomorphine (10 mg/kg s.c.) does not induce a compulsion to gnaw, but pretreatment with antihistamines, viz. pheniramine, chlorpheniramine and mepyramine, in doses ranging from 30 to 60 mg/kg i.p. caused gnawing activity. Mepyramine showed significantly less effect when compared to the othe