Potential anticancer agents VI: 5-substituted pyrimidine-6-carboxaldehydes

✍ Scribed by Chung Il Hong; Claude Piantadosi; J. Logan Irvin

• Book ID: 102914893
• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 969 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600591120

✦ Synopsis

observation that an equilibrium does not exist between the liquid surface and the film for water vapor. The resulting equation readily leads to the calculation of a permeability coefficient for the film; the units of P are the same as the diffusion coefficient, square centimeters per second. A steady state was assumed to exist within the diffusion cell following the lag time. This was justified by the linearity of the graphical data in Fig. 1. The theory was tested with films of unplasticized methylhydroxypropoxyl ethers of cellulose cast from water and an organic solventj and the permeability coefficients were calculated from the slope of l/rate versus film thickness. This provides a direct experimental method for easily determining permeability coefficients and, by maintaining constant cell geometry, relative permeability values can be assigned to any fXm or series of films. 18,457(1965).