✦ LIBER ✦

Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents

✍ Scribed by Ahmed Kamal; J. Surendranadha Reddy; M. Janaki Ramaiah; E. Vijaya Bharathi; D. Dastagiri; M. Kashi Reddy; S.N.C.V.L. Pushpavalli; Manika Pal-Bhadra

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 407 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.06.147

No coin nor oath required. For personal study only.

✦ Synopsis

A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the characteristic features of apoptosis like enhancement in the levels of p53, release of cytochrome c, and cleavage of PARP.

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