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Synthesis of Aryl-Substituted Naphthalene-Linked Pyrrolobenzodiazepine Conjugates as Potential Anticancer Agents with Apoptosis-Inducing Ability

โœ Scribed by Dr. Ahmed Kamal; M. Kashi Reddy; Dr. M. Janaki Ramaiah; Y. V. V. Srikanth; Rajender; V. Santosh Reddy; G. Bharath Kumar; Dr. S. N. C. V. L. Pushpavalli; Indira Bag; Dr. Aarti Juvekar; Dr. Subrata Sen; Dr. Surekha M. Zingde; Dr. Manika Pal-Bhadra


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
885 KB
Volume
6
Category
Article
ISSN
1860-7179

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โœ Ahmed Kamal; J. Surendranadha Reddy; M. Janaki Ramaiah; E. Vijaya Bharathi; D. D ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 407 KB

A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the cha