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Potent Inhibitors of Secretory Phospholipase A2: Synthesis and Inhibitory Activities of Indolizine and Indene Derivatives

✍ Scribed by Hagishita, Sanji; Yamada, Masaaki; Shirahase, Kazuhiro; Okada, Toshihiko; Murakami, Yasushi; Ito, Yuji; Matsuura, Takaharu; Wada, Masaaki; Kato, Toshiyuki; Ueno, Masahiko; Chikazawa, Yukiko; Yamada, Katsutoshi; Ono, Takashi; Teshirogi, Isao; Ohtani, Mitsuaki

Book ID
118009334
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
873 KB
Volume
39
Category
Article
ISSN
0022-2623

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πŸ“œ SIMILAR VOLUMES

Synthesis and enzyme inhibitory activiti
Synthesis and enzyme inhibitory activities of a series of lipidic diamine and aminoalcohol derivatives on cytosolic and secretory phospholipases A2
✍ Rut Lucas; Amalia Úbeda; Miguel PayΓ‘; Mario Alves; Esther del Olmo; JosΓ© L. LΓ³pe πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 English βš– 134 KB

We have synthesised some lipidic diamines and aminoalcohols and examined their behaviour as inhibitors of secretory and cytosolic PLA2. Some structure-activity relationships considerations have been deduced. Compound 14 was a potent and selective inhibitor of cPLA2 and compound 4 showed a dual inhib