✦ LIBER ✦

Synthesis and enzyme inhibitory activities of a series of lipidic diamine and aminoalcohol derivatives on cytosolic and secretory phospholipases A2

✍ Scribed by Rut Lucas; Amalia Úbeda; Miguel Payá; Mario Alves; Esther del Olmo; José L. López; Arturo San Feliciano

Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 134 KB
Volume: 10
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(99)00680-0

No coin nor oath required. For personal study only.

✦ Synopsis

We have synthesised some lipidic diamines and aminoalcohols and examined their behaviour as inhibitors of secretory and cytosolic PLA2. Some structure-activity relationships considerations have been deduced. Compound 14 was a potent and selective inhibitor of cPLA2 and compound 4 showed a dual inhibitory profile against both types of PLA2 while no cytotoxicity at 10 microM on human neutrophils or on murine macrophage line was observed for both.

📜 SIMILAR VOLUMES

ChemInform Abstract: Potent Inhibitors o

ChemInform Abstract: Potent Inhibitors of Secretory Phospholipase A2: Synthesis and Inhibitory Activities of Indolizine and Indene Derivatives.

✍ S. HAGISHITA; M. YAMADA; K. SHIRAHASE; T. OKADA; Y. MURAKAMI; Y. ITO; T. MATSUUR 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

Recombinant human secretory phospholipas

Recombinant human secretory phospholipase A2: Purification and characterization of the enzyme for active site studies

✍ J. M. Stadel; C. Jones; G. P. Livi; K. Hoyle; J. Kurdyla; A. Roshak; M. M. McLau 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 890 KB

## Abstract A secreted form of phospholipase A~2~ (PLA~2~) is thought to play an important role in inflammatory diseases. To characterize this enzyme the cDNA encoding a low molecular weight PLA~2~ was cloned from a human placental cDNA library. The cDNA encoding the human PLA~2~ was subcloned into

Bimodal regulatory effect of melittin an

Bimodal regulatory effect of melittin and phospholipase A2-activating protein on human type II secretory phospholipase A2

✍ K Koumanov; A Momchilova; C Wolf 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 177 KB

Melittin and phospholipase A 2 -activating protein (PLAP) are known as efficient activators of secretory phospholipase A 2 (sPLA 2 ) types I, II, and III when phospholipid liposomes are used as substrate. The present study demonstrates that both peptides can either inhibit or activate sPLA 2 dependi

Effect of a series of 1-alkyl ether lipi

Effect of a series of 1-alkyl ether lipids on inhibition of phospholipase A2activity and PAF responses

✍ C. Kohler; M. Carroll; E. Tarrant; L. Torley; A. Wissner 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 913 KB

ChemInform Abstract: Synthesis and Pharm

ChemInform Abstract: Synthesis and Pharmacological Activity of Aminoketones and Aminoalcohols of the Imidazo[1,2-a]benzimidazole Series.

✍ V. A. Anisimova; N. I. Avdyunina; A. A. Spasov; I. A. Barchan 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

ChemInform Abstract: Pyrrolidine Inhibit

ChemInform Abstract: Pyrrolidine Inhibitors of Human Cytosolic Phospholipase A2. Part 2. Synthesis of Potent and Crystallized 4-Triphenylmethylthio Derivative “Pyrrophenone”.

✍ Kaoru Seno; Takayuki Okuno; Koichi Nishi; Yasushi Murakami; Katsutoshi Yamada; S 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v