We have synthesised some lipidic diamines and aminoalcohols and examined their behaviour as inhibitors of secretory and cytosolic PLA2. Some structure-activity relationships considerations have been deduced. Compound 14 was a potent and selective inhibitor of cPLA2 and compound 4 showed a dual inhib
Effect of a series of 1-alkyl ether lipids on inhibition of phospholipase A2activity and PAF responses
β Scribed by C. Kohler; M. Carroll; E. Tarrant; L. Torley; A. Wissner
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 913 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0360-3997
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π SIMILAR VOLUMES
Melittin and phospholipase A 2 -activating protein (PLAP) are known as efficient activators of secretory phospholipase A 2 (sPLA 2 ) types I, II, and III when phospholipid liposomes are used as substrate. The present study demonstrates that both peptides can either inhibit or activate sPLA 2 dependi
Secretory phospholipase A 2 (sPLA 2 ) belongs to a family of small interfacially active enzymes that catalyze the hydrolysis of phospholipids, yielding lysolipids and fatty acids. sPLA 2 is found in snake and bee venom and also in inflammatory and cancerous tissue. It is mainly active on organized l