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POTENT IN VITRO ANTICANCER ACTIVITIES OF RING-EXPANDED (“FAT”) NUCLEOSIDES CONTAINING THE IMIDAZO[4,5- E ][1,3]DIAZEPINE RING SYSTEM

✍ Scribed by Gill, Juliana K.; Wang, Lijuan; Bretner, Maria; Newman, Rachel; Kyprianou, Natasha; Hosmane, Ramachandra S.


Book ID
127080932
Publisher
Taylor and Francis Group
Year
2001
Tongue
English
Weight
106 KB
Volume
20
Category
Article
ISSN
0732-8311

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Synthesis of a novel ring-expanded (“fat
✍ Huan-Ming Chen; Ramachandra S. Hosmane 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 33 KB

## Abstract The synthesis of 6‐amino‐4,5‐dihydro‐8__H__‐1‐(2‐phosphonylmethoxyethyl)imidazo[4,5‐__e__][1,3]diazepine‐4,8‐dione (7), a novel ring‐expanded (“fat”) acyclic nucleotide analogue of phosphonomethoxyethylguanine (PMEG), has been reported. It was prepared in 4 steps in 51% overall yield st