Potent competitive inhibition of α-galactosidase and α-glucosidase activity by 1,4-dideoxy-1,4-iminopentitols: syntheses of 1,4-dideoxy-1,4-imino-d-lyxitol and of both enantiomers of 1,4-dideoxy-1,4-iminoarabinitol
✍ Scribed by G.W.J. Fleet; S.J. Nicholas; P.W. Smith; S.V. Evans; L.E. Fellows; R.J. Nash
- Book ID
- 104228788
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 262 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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The protected compounds (V) and (IX) are treated with iodine in MeOH to give pyrrolidines (VI) and (X), respectively. Iodine is found to be an efficient catalyst for deprotection of several O-and N-protecting groups. -(KIM, J.
Deoxymannojirimycin (1,5-dideoxy-1 ,S-imino-~-mannitol) 8, 1 -deoxynojirimycin (1,5-dideoxy-I ,5-iminO-D-ghcitol) 9, and 1,4-dideoxy-1,4-imino-~-arabinitol 10 are very effective glycosidase inhibitors."," The piperidine derivatives 8 and 9 have been known for some time,"] whereas the pyrrolidine der