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Potent and selective inhibitors of human peptidylglycine α-amidating monooxygenase

✍ Scribed by Cao, Feihua; Gamble, Allan B.; Kim, Hye-Kyung; Onagi, Hideki; Gresser, Mary J.; Kerr, Jamie; Easton, Christopher J.


Book ID
119959025
Publisher
The Royal Society of Chemistry
Year
2011
Tongue
English
Weight
97 KB
Volume
2
Category
Article
ISSN
2040-2503

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Synthesis of tripeptide inhibitors of pe
✍ Mark D. Andrews; Kelly A. O'Callaghan; John C. Vederas 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 745 KB

Both enantiomers of (E)-and (Z)-2-amino-4-phenyl-3-butenoic acids (styrylglycines) 1 la,b and 12a,b, were synthesised in non-racemic form, in 7 steps starting from either D-or L-aspartic acid. (E)-Styrylglycine l la was converted to the tripeptide D-Phe-L-Phe-D-styrylglycine 15, and also to three di