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Synthesis of tripeptide inhibitors of peptidylglycine α-amidating monooxygenase (PAM) containing D- and L-styrylglycine

✍ Scribed by Mark D. Andrews; Kelly A. O'Callaghan; John C. Vederas

Book ID
104207869
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
745 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

Both enantiomers of (E)-and (Z)-2-amino-4-phenyl-3-butenoic acids (styrylglycines) 1 la,b and 12a,b, were synthesised in non-racemic form, in 7 steps starting from either D-or L-aspartic acid. (E)-Styrylglycine l la was converted to the tripeptide D-Phe-L-Phe-D-styrylglycine 15, and also to three diastereomeric tripeptides 16-18. All four tripeptides, and both enantiomers of N-acetylstyrylglycine 13a and 13b, were tested as inhibitors of peptidylglycine ~-amidating monooxygenase (PAM).

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ChemInform Abstract: Synthesis of Tripep
ChemInform Abstract: Synthesis of Tripeptide Inhibitors of Peptidylglycine α- Amidating Monooxygenase (PAM) Containing D- and L-Styrylglycine.
✍ M. D. ANDREWS; K. A. O'CALLAGHAN; J. C. VEDERAS 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB

Synthesis of Tripeptide Inhibitors of Peptidylglycine α-Amidating Monooxygenase (PAM) Containing D-and L-Styrylglycine. -The tripeptides (XI)-(XIV) do not show potent inhibition of peptidylglycine α-amidating monooxygenase. -(ANDREWS, M. D.; O'CALLAGHAN, K.