Both enantiomers of (E)-and (Z)-2-amino-4-phenyl-3-butenoic acids (styrylglycines) 1 la,b and 12a,b, were synthesised in non-racemic form, in 7 steps starting from either D-or L-aspartic acid. (E)-Styrylglycine l la was converted to the tripeptide D-Phe-L-Phe-D-styrylglycine 15, and also to three di
✦ LIBER ✦
Thiorphan, tiopronin, and related analogs as substrates and inhibitors of peptidylglycine α-amidating monooxygenase (PAM)
✍ Scribed by Neil R. McIntyre; Edward W. Lowe Jr.; Geoffrey H. Chew; Terrence C. Owen; David J. Merkler
- Book ID
- 116466298
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 874 KB
- Volume
- 580
- Category
- Article
- ISSN
- 0014-5793
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Synthesis of Tripeptide Inhibitors of Peptidylglycine α-Amidating Monooxygenase (PAM) Containing D-and L-Styrylglycine. -The tripeptides (XI)-(XIV) do not show potent inhibition of peptidylglycine α-amidating monooxygenase. -(ANDREWS, M. D.; O'CALLAGHAN, K.