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Possible role of 6-hydroxymethylbenzo[a]pyrene as a proximate carcinogen of benzo[a]pyrene and 6-methylbenzo[a]pyrene

✍ Scribed by James W. Flesher; Katherine L. Sydnor

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
329 KB
Volume
11
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Benzo[a]pyrene (B[a]P) and 6‐methylbenzo[a]pyrene ( 6‐MeB[a]P) are metabolized by fortified rat‐liver homogenates to a number of metabolites including one which is indistinguishable from 6‐hydroxymethylbenzo[a]pyrene (6–OHMeB[a]P) by either thin‐layer chromatography or ultra‐violet absorption spectra. This compound is a potent carcinogen when administered by subcutaneous injection to rats. These observations are in accord with the hypothesis that methylation or hydroxymethylation is one of the first steps in metabolic activation of carcinogenic polycyclic hydrocarbons.

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