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Population-Based Mechanistic Prediction of Oral Drug Absorption

โœ Scribed by Masoud Jamei; David Turner; Jiansong Yang; Sibylle Neuhoff; Sebastian Polak; Amin Rostami-Hodjegan; Geoffrey Tucker


Book ID
111767555
Publisher
American Association of Pharmaceutical Scientists
Year
2009
Tongue
English
Weight
491 KB
Volume
11
Category
Article
ISSN
1550-7416

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โœ G. Valsami; P. Macheras ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 459 KB

## Abstract Early prediction of human intestinal absorption is important in selection of potential orally administered drugs. Various computational models for prediction of the fraction of dose absorbed, __Fa__, have been developed. In 1989, a sigmoidal relationship between __Fa__ and drug absorpti