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Computational Prediction of Oral Drug Absorption Based on Absorption Rate Constants in Humans

✍ Scribed by Linnankoski, Johanna; Mäkelä, Johanna M; Ranta, Veli-Pekka; Urtti, Arto; Yliperttula, Marjo


Book ID
111962881
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
235 KB
Volume
49
Category
Article
ISSN
0022-2623

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✍ G. Valsami; P. Macheras 📂 Article 📅 2011 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 459 KB

## Abstract Early prediction of human intestinal absorption is important in selection of potential orally administered drugs. Various computational models for prediction of the fraction of dose absorbed, __Fa__, have been developed. In 1989, a sigmoidal relationship between __Fa__ and drug absorpti