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Ponatinib in Refractory Philadelphia Chromosome–Positive Leukemias

✍ Scribed by Cortes, Jorge E.; Kantarjian, Hagop; Shah, Neil P.; Bixby, Dale; Mauro, Michael J.; Flinn, Ian; O'Hare, Thomas; Hu, Simin; Narasimhan, Narayana I.; Rivera, Victor M.; Clackson, Tim; Turner, Christopher D.; Haluska, Frank G.; Druker, Brian J.; Deininger, Michael W.N.; Talpaz, Moshe


Book ID
118218196
Publisher
Massachusetts Medical Society
Year
2012
Tongue
English
Weight
608 KB
Volume
367
Category
Article
ISSN
0096-6762

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Dasatinib treatment for Philadelphia chr
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## Abstract Dasatinib is a highly potent Bcr‐Abl inhibitor that is approved for the treatment of imatinib‐resistant or ‐intolerant chronic myeloid leukemia (CML) and Philadelphia chromosome‐positive acute lymphoblastic leukemia. Across a series of phase 2 and 3 trials, dasatinib was associated with