Dasatinib in Imatinib-Resistant Philadelphia Chromosome–Positive Leukemias
✍ Scribed by Talpaz, Moshe; Shah, Neil P.; Kantarjian, Hagop; Donato, Nicholas; Nicoll, John; Paquette, Ron; Cortes, Jorge; O'Brien, Susan; Nicaise, Claude; Bleickardt, Eric; Blackwood-Chirchir, M. Anne; Iyer, Vishwanath; Chen, Tai-Tsang; Huang, Fei; Decillis, Arthur P.; Sawyers, Charles L.
- Book ID
- 120754800
- Publisher
- Massachusetts Medical Society
- Year
- 2006
- Tongue
- English
- Weight
- 443 KB
- Volume
- 354
- Category
- Article
- ISSN
- 0096-6762
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## Abstract Dasatinib is a highly potent Bcr‐Abl inhibitor that is approved for the treatment of imatinib‐resistant or ‐intolerant chronic myeloid leukemia (CML) and Philadelphia chromosome‐positive acute lymphoblastic leukemia. Across a series of phase 2 and 3 trials, dasatinib was associated with
## Abstract ## BACKGROUND Initial treatment for adult patients with Philadelphia chromosome‐positive (Ph[+]) chronic myelogenous leukemia (CML) now includes imatinib mesylate. However, to our knowledge, there are few data regarding imatinib safety, efficacy, and response monitoring in patients age