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Modeling Philadelphia chromosome positive leukemias

✍ Scribed by Witte, Owen N; Wong, Stephane

Book ID
110065891
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
414 KB
Volume
20
Category
Article
ISSN
0950-9232

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The molecular basis of the Philadelphia chromosome (Ph') is a structurally altered c-abl (bcr-abl) gene which encodes an abnormally large protein with protein tyrosine kinase activity. Herbimycin A, which effectively reduced intracellular phosphorylation by bcr-abl tyrosine kinase, preferentially in