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Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer

✍ Scribed by Tasha R. Smith; Mark Steven Miller; Kurt Lohman; Ethan M. Lange; L.Douglas Case; Harvey W. Mohrenweiser; Jennifer J. Hu

Book ID
117467606
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
110 KB
Volume
190
Category
Article
ISSN
0304-3835

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## Abstract Cigarette smoke can generate reactive oxygen species, which are capable of inducing double‐strand breaks (DSBs) in DNA. Polymorphisms in __XRCC2__ and __XRCC3__ genes, involved in DSBs repair pathways, may alter an individual's susceptibility to smoking‐related cancers. We investigated