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Polymorphisms of DNA repair genes, XRCC1 and XRCC3, and susceptibility to familial prostate cancer in a Japanese population

✍ Scribed by Tatsuya HAMANO; Hiroshi MATSUI; Nobuaki OHTAKE; Seiji NAKATA; Kazuhiro SUZUKI


Book ID
111318666
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
72 KB
Volume
4
Category
Article
ISSN
1743-7555

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## Abstract Cigarette smoke can generate reactive oxygen species, which are capable of inducing double‐strand breaks (DSBs) in DNA. Polymorphisms in __XRCC2__ and __XRCC3__ genes, involved in DSBs repair pathways, may alter an individual's susceptibility to smoking‐related cancers. We investigated