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DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract

✍ Scribed by Simone Benhamou; Jarno Tuimala; Christine Bouchardy; Pierre Dayer; Alain Sarasin; Ari Hirvonen

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
71 KB
Volume
112
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Cigarette smoke can generate reactive oxygen species, which are capable of inducing double‐strand breaks (DSBs) in DNA. Polymorphisms in XRCC2 and XRCC3 genes, involved in DSBs repair pathways, may alter an individual's susceptibility to smoking‐related cancers. We investigated the effect of XRCC2 Arg^188^His and XRCC3 Thr^241^Met polymorphisms in cancer proneness in 121 oral/pharynx cancer cases, 129 larynx cancer cases and 172 noncancer controls, all Caucasian smokers. The XRCC2 His‐allele was associated with a significantly increased risk of pharyngeal cancer (OR=2.9, 95% CI: 1.3–6.2). No significant associations were observed between the XRCC3 Thr^241^Met polymorphism and overall risk of developing UADT cancers. However, quite opposite to the expectations, a reduced risk of supraglottic cancer was found for carriers of the XRCC3 Met variant allele (OR=0.3, 95% CI: 0.2–0.7). These findings provide evidence for the view that polymorphisms in DNA repair genes may modify individual susceptibility to smoking‐related cancers. © 2004 Wiley‐Liss, Inc.

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