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Polymorphisms in theUBC9andPIAS3genes of the SUMO-conjugating system and breast cancer risk

✍ Scribed by Thomas Dünnebier; Justo Lorenzo Bermejo; Susanne Haas; Hans-Peter Fischer; Christiane B. Pierl; Christina Justenhoven; Hiltrud Brauch; Christian Baisch; Michael Gilbert; Volker Harth; Anne Spickenheuer; Sylvia Rabstein; Beate Pesch; Thomas Brüning; Yon-Dschun Ko; Ute Hamann

Publisher
Springer US
Year
2009
Tongue
English
Weight
258 KB
Volume
121
Category
Article
ISSN
0167-6806

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## Abstract Caspase‐3 (CASP‐3) is a primary effector CASP that executes programmed cell death, and it plays an important role in the development and progression of cancer. Polymorphisms in the __CASP‐3__ gene may influence CASP‐3 production and/or activity, thereby modulating the susceptibility to