Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women
✍ Scribed by Malin Bergman; Marie Ahnström; Pia Palmebäck Wegman; Sten Wingren
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- English
- Weight
- 214 KB
- Volume
- 131
- Category
- Article
- ISSN
- 1432-1335
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## Abstract Prostate cancer continues to be the most frequently diagnosed neoplasm, and the second leading cause of cancer‐related mortality in men. Oxidative stress may enhance prostatic carcinogenesis. Manganese superoxide dismutase (MnSOD) is the only known superoxide scavenger in mitochondria.
Long-term exposure to oestrogens is a well-recognised risk factor for breast cancer, whereas little is known about the influence of polymorphisms of genes involved in oestrogen biosynthesis and metabolism. A candidate, containing a single bp polymorphism, T8C, (designated, A2 allele), might be the C