Polymorphism in glutathione S-transferases: Susceptibility and treatment outcome for head and neck cancer
β Scribed by Ruwali, Munindra; Singh, Madhu; Pant, Mohan C.; Parmar, Devendra
- Book ID
- 124061041
- Publisher
- Informa plc
- Year
- 2011
- Tongue
- English
- Weight
- 672 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0049-8254
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## Abstract ## Background. Factors determining the individual susceptibility to head and neck squamous cell carcinoma (HNSCC) are still largely unknown. An imbalance between enzymes involved in the toxification and detoxification of (pre)βcarcinogens closely related to HNSCC, which may appear duri
Background. The purpose of this study was to evaluate the prognostic ability of polymorphisms of three genes involved in the metabolism of tobacco carcinogens (GSTT1, GSTM1, GSTP1) and one polymorphism of a DNA repair gene (XRCC1) for patients diagnosed with squamous cell carcinoma (SCC). Methods.