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Polymorphisms of the glutathione S-transferase P1 gene and head and neck cancer susceptibility

✍ Scribed by Michael B. Oude Ophuis; Hennie M. J. Roelofs; Piet A. van den Brandt; Wilbert H. M. Peters; Johannes J. Manni

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 86 KB
Volume: 25
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.10182

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✦ Synopsis

Abstract

Background.

Factors determining the individual susceptibility to head and neck squamous cell carcinoma (HNSCC) are still largely unknown. An imbalance between enzymes involved in the toxification and detoxification of (pre)‐carcinogens closely related to HNSCC, which may appear during smoking and alcohol consumption, may play a role. Genetic polymorphisms in glutathione S‐transferases (GSTs) often result in altered detoxification, which may contribute to individual susceptibility to HNSCC.

Methods.

We studied the frequencies of polymorphic variants in the GSTP1 gene in 235 patients with HNSCC and 285 healthy controls. In addition, data on exposure to alcohol and tobacco consumption were recorded. DNA was extracted from whole blood, and polymerase chain reaction–based methods were used to detect genetic polymorphisms.

Results.

In patients with HNSCC and control groups, the homozygous GSTP1 BB genotype was observed in 12.3% and 13.6%, respectively. No statistical differences were found for the GSTP1 AA and GSTP1 AB/GSTP1BB genotypes.

Conclusions.

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